oaPHARMACOLOGY dogmas and Methods of assay Prof. Ramesh K. Goyal L. M. College of Pharmacy Navrangpura Ahmedabad- 380 009 (18.01.2008) CONTENTS splendour of Bioassay Principle of Bioassay Methods of Bioassay for Agonists Bioassay of Antagonists Bioassay of some primal medicates period status of Bioassay in different Pharmacopoeia early(a) formal Bioassays Keywords Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase,diphtheria vaccine, plague vaccine 1 Bioassay is defined as the estimation of the potency of an sprightly linguistic rule in a unit quantity of provision or detection and step of the concentration of the substance in a preparation employ biological methods (i.e. observation of pharmacologic effects on animate tissues, microorganisms or immune cells or animal). Hence micro assay, radioimmunoassay argon also regarded as ` assay. latter ly `biotechnology has also been considered for bioassay. Bioassay of the products wish well erythropoietin, hepatitisB vaccine and so forth is being done through biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g.
chemical or tangible assay) are little accurate, less elaborate, more laborious, more troublesome and more expensive. However, bioassay is the only method of assay if (1) active voice principle of drug is unknown or can non be isolated, e.g. insulin, keister pituitary extract etc. (2) Chemical method is whatsoever not available or if available, it is too com plex and insensitive or requires higher do! se e.g. insulin, acetylcholine. (3) Chemical composition is not known, e.g. long acting thyroid stimulants. (4) Chemical composition of drug differs but have the same pharmacological action and vice-versa, e.g. cardiac glycosides, catecholamines etc. Moreover, even if chemical methods are available and the results of bioassay conflict with those of the chemical assay,...If you want to get a epic essay, order it on our website: BestEssayCheap.com
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